Garcinol and Anacardic Acid, Natural Inhibitors of Histone Acetyltransferases, Inhibit Rhabdomyosarcoma Growth and Proliferation

Rhabdomyosarcoma (RMS) is a malignant tumour of the soft tissues. There are two main histopathological types: alveolar and embryonal. RMS occurs mainly in childhood result deregulation growth differentiation muscle cell precursors. an increasing amount data indicating that numerous epigenetic alterations within chromatin histone proteins involved pathogenesis this malignancy. Histone acetylation one most important modifications catalysed by enzymes from group acetyltransferases (HAT). In study, impact natural acetyltransferase inhibitors (HATi)—garcinol (GAR) anacardic acid (AA)—on biology cells was evaluated through series vitro tests measuring proliferation, viability, clonogenicity, cycle apoptosis. Moreover, using oligonucleotide microarrays real-time PCR, we identified several genes whose expression changed after GAR AA treatment. The examined HATi significantly reduce invasive phenotype inhibiting rate, viability clonogenic abilities. What more, these substances cause arrest G2/M phase, induce apoptosis affect genetic endoplasmic reticulum stress sensors. may serve as promising potential anti-cancer drugs since they sensitize to chemotherapeutic